Limbic encephalitis associated with antibodies to the NMDA receptor in Hodgkin lymphoma (Zandi et al, Neurology, 2009)
Abstract: "Convulsions, fever, and memory loss after chemotherapy are usually due to opportunistic infection, and often attributed to infection even if CSF viral PCR examination is negative. We describe a case of limbic encephalitis in a patient with relapsed Hodgkin lymphoma, in whom antibodies to the NMDA receptor were identified in serum and CSF, and whose anterograde memory improved with aggressive immunotherapy. Paraneoplastic limbic encephalitis in Hodgkin lymphoma has been reported before,1,2 but no target antigen identified. The case adds to the clinical associations of NMDA receptor antibodies."
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